In a groundbreaking study, researchers at the Indian Institute of Science (IISc) have pinpointed a pivotal gene crucial for the survival and persistence of Mycobacterium tuberculosis (Mtb) within the human body. Published in Science Advances, this discovery marks a significant stride in combatting tuberculosis (TB), a global health menace.
Led by Amit Singh, the team uncovered that the IscS gene regulates iron-sulphur clusters vital for Mtb’s survival in oxygen-deprived lung regions. This gene orchestrates the SUF operon’s activation, allowing the bacterium to persist stealthily. Deleting IscS resulted in a severe disease form in mouse models, shedding light on its role in maintaining chronic infections.
Moreover, the mutant strain displayed increased vulnerability to specific antibiotics, hinting at potential treatment strategies. Targeting IscS and SUF systems with a medication combination could revolutionize TB therapy.
This breakthrough not only elucidates TB’s persistence mechanisms but also heralds prospects for novel therapies, aiming to eradicate this global health threat. The IISc research lays a foundation for transformative advancements in TB treatment, promising hope for a TB-free world.
